Introduction: BASIC LIFE SUPPORT ((BLS)) is a medical treatment used in LIFE-threatening emergencies until the sufferer can be properly cared for by a team of paramedics or in a hospital. This study aimed to assess the level of knowledge regarding (BLS) and the contributing factors among the Arab non-medical population. Methods: An online survey-based cross-sectional study was conducted among non-medical populations in nine Arab countries between April 13, 2022, and June 30, 2022. The utilized questionnaire consisted of two parts: part one included socio-demographic characteristics and part two measured knowledge of (BLS) through an online survey. Results: The research included a total of 4465 participants. 2540 (56. 89%) of the participants were knowledgeable about (BLS). Themean BASIC LIFE SUPPORT knowledge scores of participants who received training were higher than those who had not (20. 11 ±,4. 20 vs. 16. 96 ±,5. 27,p< 0. 01). According to the nations, Yemen scored the highest, whileMorocco had the lowest levels of (BLS) knowledge (19. 86 ±,4. 71 vs. 14. 15 ±,5. 10, respectively,p< 0. 01). Additionally, individuals who resided in urban areas scored on average higher than those who did in rural areas (17. 86 ±,5. 19 vs. 17. 13 ±,5. 24, p= 0. 032) in understanding BASIC LIFE SUPPORT. Age, information sources, and previous training with theoretical and practical classes were significant predictors of (BLS) knowledge. Conclusion: The level of (BLS) knowledge among non-medical people in Arab nations is moderate but insufficient to handle the urgent crises that we face everywhere. In addition to physicians being required to learn the (BLS) principles, non-medical people should also be knowledgeable of the necessary actions to take in emergency events.